The original design was unveiled at the Tokyo International Anime Fair 2009.[28] The opening theme is "The Realm of Athena" by EUROX, and the ending theme is "Leash of Flower" (花の鎖, Hana no Kusari?), by Maki Ikuno featuring Marina del Ray. The remaining tracks were developed by Kaoru Wada.

# Title Original airdate
01 "Promise"

"Yakusoku" (約束)

June 24, 2009
02 "Awakening of Hades"

"Hādesu kakusei" (ハーデス覚醒)

June 24, 2009
03 "The Holy War Starts"

"Seisen shidō" (聖戦始動)

August 21, 2009
04 "The Prayer Wreath"

"Inori no hanawa" (祈りの花輪)

August 21, 2009
05 "Poison Rose"

"Doku bara" (毒薔薇)

October 21, 2009
06 "Procession of Funeral Flowers"

"Hana sōretsu" (花葬列)

October 21, 2009
07 "Fruit of the Sapindus"

"Mokurenji no mi" (木欒子の実)

December 23, 2009
Yuzuriha reveals to Tenma and Yato that their real mission is to pick the fruits of the legendary Sapindus tree that grows in the underworld. On their way, they are found by Hell's Watchdog Cerberus and Alone, who tries to lure the Pegasus Saint into his army and then reveals his plans to invade the Sanctuary. As the last and most unexpected obstacle, Tenma is challenged by the ominous Virgo Asmita, who seems to doubt Athena's capacity to keep peace in the world.
08 "Day of Breeze"

"Yoki kaze no hi" (良き風の日)

December 23, 2009
Picking 108 fruits of the Sapindus tree, Tenma, Yato and Yuzuriha start their way back to the world of the living. Meanwhile, Specters head towards Jamir and find themselves caught in Virgo Asmita's trap. Returning to life, Tenma, Yato and Yuzuriha are reunited with Hakurei, who explains the true purpose behind the fruits of the Sapindus tree: they will be able to seal the Specters' souls and prevent their resurrection; however, in order to do that, they need to be empowered by the essence of cosmo: the Eight Sense.
09 "Giant Star"

"Kyosei" (巨星)

February 23, 2010
Minos' Specters, previously killed by Pisces Albafica's Bloody Rose trap, are brought back to life. Now, they find themselves face to face with Taurus Aldebaran, who proves to be capable of dealing with them with his arms crossed. While Aldebaran and Dohko patrol the Sanctuary's vicinity, Bennu Kagaho arrives, seeking revenge against the Libra Saint — however, he meets Taurus instead, and they start a furious battle: the fastest Specter against the fastest Gold Saint.
10 "Descent"

"Kōrin" (降臨)

February 23, 2010
The fight between Aldebaran and Kagaho reaches its climax. Bennu recalls old memories with the arrival of the Taurus Saint's disciples, and decides to take on his opponent with full power; on the other hand, Aldebaran decides to unleash his most powerful technique in order to end the battle. During the night, peace is shaken: Alone himself invades the Sanctuary and wreaks destruction, forcing the Gold Saints into submission with his grand Cosmo. It's time for Athena to face her legendary enemy — and for Sasha, to face her older brother.
11 "Now Unreachable"

"Mō todokanai" (もう届かない)

April 21, 2010
12 "Sacrifice That Will Not Fade"

"Taenai gisei" (絶えない犠牲)

April 21, 2010
13 "The Journey Starts"

"Tabidachi" (旅立ち)

April 21, 2010